Fig. 5

CSF biomarker concentrations in the patients of CSF protein (A), S100 (B), NSE (C), Phospho-Tau (D), Tau protein (E) and β-Amyloid 1–42 (F) compared between AD− and AD+. Horizontal lines within boxes show median values, boxes show upper and lower interquartile ranges, whiskers indicate the 95% confidence interval, a cross (x) in the figure indicate outlier values. AD−: Alzheimer negative, AD+ : Alzheimer positive. B: baseline visit (recruitment), T1: follow-up visit (< 6 month), T2: follow-up visit (> 6 month). T2: study visit more than 6 month (> 6 M.). S100: S100 protein; NSE: neuron-specific enolase; T-Tau: total Tau; P-Tau: Tau phosphorylated at threonine 181; Aβ42: Amyloid-β 1–42 protein. Differences analyzed with Mann Whitney U test. *p < 0.05, **p < 0.01, ***p < 0.001