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Fig. 1 | Neurological Research and Practice

Fig. 1

From: Macrophage inclusions in cerebrospinal fluid following treatment initiation with antisense oligonucleotide therapies in motor neuron diseases

Fig. 1

Macrophages of an adult patient with SMA (A) and an adult patient with SOD1-ALS (D) before ASO treatment (treatment-naive): Normal configuration with typical irregular nuclear contour and multiple intracytoplasmic vacuoles (1000x, May-Grunwald-Giemsa staining). Macrophages of the same adult patients with SMA (B & C) and SOD1-ALS (E & F) during ASO treatment presenting with eosinophilic and basophilic inclusion bodies. Occasionally, macrophages with inclusions appeared with contact to lymphocytes (E, red arrow) (1000x, May-Grunwald-Giemsa staining). ASO: antisense oligonucleotide; SMA: 5q-associated spinal muscular atrophy; SOD1-ALS: superoxide dismutase 1 mutation-associated amyotrophic lateral sclerosis

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Neurological Research and Practice

ISSN: 2524-3489

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